Our Joint Relief cream is made with Cayenne peppers grown right here on the homestead. Capsaicin, the main active constituent of cayenne pepper, has a numbing effect when used topically, which helps in providing fast relief from joint pain. Studies have shown that capsaicin selectively targets the pain receptors. Hence, it is safe for topical use. 2oz. Great for RA (rheumatoid arthritis) or sore joints.